Radioligand therapy-personalized treatment for patients with neuroendocrine tumors

Over the past 2 decades, radioligand therapy (RLT), previously referred to as peptide receptor radionuclide therapy, has been proven to be an effective and safe therapeutic option in patients with advanced, unresectable, often progressive, well-differentiated neuroendocrine tumors. The NET TER-1 study, the only randomized phase-III trial to date, established RLT with 177Lu-DOTATATE as the "gold standard" in the treatment of metastatic or locally advanced tumors, which are unresectable, well-differentiated with somatostatin receptor (SSTR) expression, and progressive neuroendocrine tumors.