Physicochemical characterization tungsten oxide modified hydroxyapatite embedded into polylactic acid nanocomposite for biomedical applications

To compensate for the feeble antimicrobial potential of hydroxyapatite (HAp), the compound has been incor-porated into different nanocomposites (NCs) in addition to powder and fibrous structure. Hydroxyapatite (HAp)/ tungsten oxide/graphene oxide (GO) ternary nanocomposite introduces a significant enhance in the cell viability to 96.7 +/- 3% towards the osteoblast cells. The chemical compositions were approved by various analytical techniques such as XRD, FTIR, XPS, and EDS. TEM shows well-defined, rod-like HAp grains. The triple ingredient HAp/WO3/GO nano-composite exhibits an 22.8 nm grain size. FESEM introduces grain shape deviation via changing HAp additives from semi-spherical to needle-like with macro-porous structure within the composite of HAp/WO3/GO. Moreover, compatibility of ternary nanocomposite inside the PLA environment led to decrease in the contact angle of the nanofibrous structure reached 16.5 +/- 4.4 degrees. The combination of HAp and organic/ inorganic elements might represent a good characterization for the target biological applications. HAp/WO3/GO composite exhibits a significant improvement in anti-microbial activity to be around 85.6 +/- 1.6 % and 110.1 +/- 2.0 % in for E. coli and S. aureus.