Survival dependant upon site of colorectal cancer and timing of liver metastasis after hepatectomy

Factors affecting overall survival (OS) after hepatectomy for colorectal cancer liver metastases (CRCLM) are unknown. This study aimed to investigate the effect of the location of the primary tumor and the timing of liver metastases on OS in patients with CRCLM who underwent hepatectomy. Patients with CRCLM who underwent hepatectomy between August 2005 and December 2019 were retrospectively enrolled in this study, at our institution. In total, 87 patients with CRCLM who underwent hepatectomy were included in this study. The primary tumor was located on the right and left sides in 27 (31%) and 60 (69%) patients, respectively. A total of 53 (61%) and 34 (39%) patients had synchronous and metachronous liver metastases, respectively. The median OS period for all patients was 31 (interquartile range [IQR], 21.3-40.7) months. The median OS periods in the right and left-sided groups were 26 (IQR, 11.7-40.3) and 32 (IQR, 23.1-40.8) months, respectively. There was no significant difference between the two groups. The median OS periods for the synchronous and metachronous groups were 26 (IQR, 21.5-30.5) and 76 (IQR, 28.2-123.8; P = 0.001) months, respectively. Cox proportional hazards model analysis showed that synchronous liver metastases were associated with poorer OS. The hazard ratio was 2.405 (95% confidence interval, 1.364-4.240; P = 0.002) Primary tumor location has no effect on OS after hepatectomy in patients with CRCLM. Synchronous liver metastases are associated with poorer OS after hepatectomy in patients with CRCLM.