Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF-κB/NLRP3 signaling pathway

Si-Jia Peng,Ya Feng,Xuan Li,Xi-Xi Wang,Yu Wang,Bu-Tian Zhou,Ye Liu,Te Liu,Yun-Cheng Wu

INTERNATIONAL IMMUNOPHARMACOLOGY（2023）

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摘要

•TP-5 exerts neuroprotective effects by inhibiting microglial inflammatory activation in vivo and in vitro.•TP-5 alleviates motor deficits, and ameliorates neuronal injury and dopaminergic degeneration in LPS mice.•TP-5 modulates NF-κB/NLRP3 signaling pathway activation.•TP-5 has therapeutic potential for inflammatory and neurodegenerative disease.

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关键词

Neurodegenerative disease, Neuroinflammation, thymopentin (TP-5), NF-kappa B, NLRP3

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