CMV Infection After Letermovir Primary Prophylaxis Discontinuation in Allogeneic Hematopoietic Cell Transplant Recipients

Lara Chavaz,Lena Royston,Stavroula Masouridi-Levrat,Anne-Claire Mamez,Federica Giannotti,Sarah Morin,Christian Van Delden,Yves Chalandon,Dionysios Neofytos

OPEN FORUM INFECTIOUS DISEASES（2023）

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摘要

In this single-center study of 61 allogeneic hematopoietic cell transplant (HCT) recipients receiving letermovir primary cytomegalovirus (CMV) prophylaxis for the first 100 days, we report 23% incidence of clinically significant CMV infection during the first 100 days after letermovir discontinuation, predominately in haploidentical HCT recipients, without any associations with CMV-DNAemia under letermovir.

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关键词

letermovir primary prophylaxis discontinuation,allogeneic hematopoietic cell transplant,infection

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