The Role of Autotaxin and LPA Signaling in Embryonic Development, Pathophysiology and Cancer

Christiana Magkrioti,Eleanna Kaffe,Vassilis Aidinis

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES（2023）

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摘要

Autotaxin (ATX) or Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) is a secreted enzyme with lysophospholipase D activity, with its primary function being the extracellular hydrolysis of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid [...].

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autotaxin,embryonic development,lpa,cancer

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