Synthesis, characterization and biological activity of schiff and azo-schiff base ligands

Schiff and azo-Schiff base derivatives were synthesized, identified and evaluated for their antimicrobial and antifungal activities against gram -positive bacteria, gram-negative bacteria and fungi such as Escherichia coli, Pseudomonas aureginosa, Staphylococcus aureus, Bacilus cereus, Salmonela typhimurium, Saccharomyces cerevisiae and Candida albicans. Chiral amides (2a -e) were synthesised by using D-Phenylglycine, L-Phenylalanine, L-valine, L-isoleucine and L-methionine. Experimental studies include the use of chiral amide derivatives (2a -e) of the five amino acids to synthesize the Schiff and azo-Schiff base derivatives of amides (3a -e, 4a -c and 4e). The structures of the compounds were determined by spectroscopic analyses (FTIR, 1H-NMR, 13C-NMR) and elemental analysis. Among the tested compounds, compound 3b and 3d were found to show the most potent inhibitory action against Gram positive and Gram negative bacteria.