Deacylative Allylation Reaction: A promising Approach for the Synthesis of Compounds Containing the Allyl Group at Quaternary Centers

This review highlights a palladium-catalyzed allylation strategy named deacylative allylation (DaA) of alpha,alpha-dialkylated beta-acetyl esters, amides, nitriles, or nitro group (EWG) in the presence of allylic alcohols. A retro-Claisen like reaction generates in situ the enolate of these groups while the resulting allyl acetate leads to the formation of the pi-allylpalladium. This alternative allows the synthesis of compounds with allyl groups at quaternary centers using mild conditions, embracing high tolerance for functional groups, and selectivity control. This approach has been used in the synthesis of natural products and bioactive compounds.