Limit-Defying mu-Total Analysis System: Achieving Part-Per- Quadrillion Sensitivity on a Hierarchical Optofluidic SERS Sensor
ACS OMEGA(2023)
摘要
Optofluidic sensors have accelerated the growth of smart sensor platforms with improved sensitivity, reliability, and innovation. In this article, we report the integration of a surface-enhanced Raman scattering (SERS) material consisting of silver nanoparticle-decorated diatomaceous earth (AgNPs-DE) with a flow-through microfluidic device, building up a hierarchical structured micro-total analysis system (mu-TAS) capable of achieving part-per-quadrillion (ppq)-level sensitivity. By the synergic integration of millimeter-scale microfluidic devices and porous laboratory filter paper with a micrometer-sized crosslinked cellulosic network that carries SERS-active AgNPs-DE, which possesses submicron to nanometer regimes of photonic crystals and plasmonic nanostructures, we achieved enhanced mass-transfer efficiency and unprecedented detection sensitivity. In our experiment, fentanyl as the testing analyte at different concentrations was measured using a portable Raman spectrometer. The limit of detection (LOD) was estimated to be 10 ppq from a small detection volume of 10 mL with an ultrafast time of sensing (TOS) of 3 min. To attain comparable signals, the traditional soaking method took more than 90 min to detect 10 part-per-trillion fentanyl from a 10 mL sample. Compared with existing SERS sensing results of fentanyl, the limit-defying mu-TAS reduced the LOD-TOS product by almost 4 orders of magnitude, which represents a new stage of ultrafast sensing of extremely low concentration analytes.
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