Genetic polymorphism of IL-17F rs763780 contributes to the susceptibility to bipolar disorder but not to schizophrenia in the Turkish population.

This study aims to investigate the genetic polymorphism in the interleukin-17F () (rs763780, 7488 A/G) gene in bipolar disorder (BD) and schizophrenia (SCZ) patients by comparing it with healthy controls considering clinical parameters. A sample of 107 patients with BD, 129 patients with SCZ, and 100 healthy volunteers were included. SCID-I was used to confirm the diagnosis according to DSM-IV-TR criteria. The Young Mania Rating Scale (YMRS) and the Hamilton Depression Rating Scale (HAM-D) were administered to BD patients. The Positive and Negative Symptoms Scale (PANSS) was applied to the patients with SCZ. PCR-RFLP was used to determine gene polymorphism. Our results demonstrated that the distributions of the genotype and the allele frequencies of BD patients were statistically significantly different from the control group. The AA genotype (OR: 0.283; 95% Cl: 0.140-0.573; <.001) and A allele (OR: 0.333; 95% Cl: 0.171-0.646; =.001) frequencies were significantly higher in the control group than in the BD group. The genotype and the allele frequency distributions of SCZ patients were not statistically significantly different from the control group. When comparing scale scores due to the genotype distributions in patients with BD or SCZ, there was no statistically significant difference between the groups of genotypes. In summary, whereas the polymorphism may be associated with BD, this polymorphism was not related to SCZ.