6-Gingerol-derived semisynthetic analogs mitigate oxidative stress, and reverse acrylamide induced neurotoxicity in zebrafish

A semisynthetic strategy has been developed for the synthesis of novel 6-gingerol based analogs using simple and robust chemistries. These newer analogs were able to quench ROS and RNS in vitro, and retrieve the oxidative stress induced by acrylamide in zebrafish larvae. They are also capable of restoring the locomotion behavior in zebrafish.