The Synthesis and Biological Activity of Organotin Complexes with Thio-Schiff Bases Bearing Phenol Fragments.

A number of novel di- and triorganotin(IV) complexes - (PhSnL, PhSnL, EtSnL, PhSnL, PhSnL) with mono- or dianionic forms of thio-Schiff bases containing antioxidant sterically hindered phenol or catechol fragments were synthesized. Compounds - were characterized by H, C NMR, IR spectroscopy, and elemental analysis. The molecular structures of complexes and in the crystal state were established by single-crystal X-ray analysis. The antioxidant activity of new complexes as radical scavengers was estimated in DPPH and ABTS assays. It was found that compounds and with free phenol or catechol fragments are more active in these tests than complexes - with tridentate O,N,S-coordinated ligands. The effect of compounds - on the promoted oxidative damage of the DNA by 2,2'-azobis(2-amidinopropane) dihydrochloride and in the process of rat liver (Wistar) homogenate lipid peroxidation in vitro was determined. Complexes and were characterized by more pronounced antioxidant activity in the reaction of lipid peroxidation in vitro than compounds -. The antiproliferative activity of compounds - was investigated against MCF-7, HTC-116, and A-549 cell lines by an MTT test. The values of IC are significantly affected by the presence of free antioxidant fragments and the coordination site for binding.