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Selection, Optimization and Validation of Ten Chronic Disease Polygenic Risk Scores for Clinical Implementation in Diverse US Populations

Niall J. Lennon,Leah C. Kottyan,Christopher Kachulis,Noura S. Abul-Husn,Josh Arias,Gillian Belbin,Jennifer E. Below,Sonja I. Berndt,Wendy K. Chung,James J. Cimino,Ellen Wright Clayton,John J. Connolly,David R. Crosslin,Ozan Dikilitas,Digna R. Velez Edwards,QiPing Feng,Marissa Fisher,Robert R. Freimuth,Tian Ge,Sonja Berndt,Joseph T. Glessner,Adam S. Gordon,Candace Patterson,Hakon Hakonarson,Maegan Harden,Margaret Harr,Joel N. Hirschhorn,Clive Hoggart,Li Hsu,Marguerite R. Irvin,Gail P. Jarvik,Elizabeth W. Karlson,Atlas Khan,Amit Khera,Krzysztof Kiryluk,Iftikhar Kullo,Katie Larkin,Nita Limdi,Jodell E. Linder,Ruth J. F. Loos,Yuan Luo,Edyta Malolepsza,Teri A. Manolio,Lisa J. Martin, Li McCarthy,Elizabeth M. McNally,James B. Meigs,Tesfaye B. Mersha,Jonathan D. Mosley,Anjene Musick,Bahram Namjou,Nihal Pai,Lorenzo L. Pesce,Ulrike Peters,Josh F. Peterson,Cynthia A. Prows,Megan J. Puckelwartz,Heidi L. Rehm,Dan M. Roden,Elisabeth A. Rosenthal,Robb Rowley,Konrad Teodor Sawicki,Daniel J. Schaid,Roelof A. J. Smit,Johanna L. Smith,Jordan W. Smoller,Minta Thomas,Hemant Tiwari,Diana M. Toledo,Nataraja Sarma Vaitinadin,David Veenstra,Theresa L. Walunas,Zhe Wang,Wei-Qi Wei,Chunhua Weng,Georgia L. Wiesner,Xianyong Yin,Eimear E. Kenny

NATURE MEDICINE（2024）

引用 21|浏览149
关键词
Polygenic Risk Scores,Pathogenicity Prediction,Genetic Testing,Precision Medicine
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