Upregulation of P2Y14 receptor in neutrophils promotes inflammation after myocardial ischemia/reperfusion injury

Kunsheng Li,Pengyu Zhou,Jie Li,Yongqing Cheng,Shiliang Li, Yumeng Wang, Weipeng Jiang, Yang Bai,Hailong Cao,Dongjin Wang

Life Sciences（2023）

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摘要

•P2Y14 receptor was highly expressed in the infarct area of the heart tissue after cardiac infarction/repersusion injury.•P2Y14 receptor was induced by UDP-Glu in neutrophils.•P2Y14 receptor antagonist PPTN promotes polarization of neutrophils to N2 phenotype.

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关键词

p2y14 receptor,neutrophils,inflammation,myocardial ischemia/reperfusion

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