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肠道屏障在肥胖相关代谢性疾病发生发展中的作用

Wang Shan,Ni Yan,Fu Junfen

Journal of Chongqing Medical University(2023)

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Abstract
随着肥胖人口所占比例增加,非酒精性脂肪肝(nonalcoholic fatty liver disease,NAFLD)和2型糖尿病(type 2 diabetes mellitus,T2DM)等肥胖相关代谢性疾病发病率逐年上升,给家庭及社会带来沉重负担.大量实验数据证实肠道屏障损伤在肥胖相关代谢性疾病的发生发展过程中起重要作用.本文详细总结了肠道屏障的结构、功能及评估方法,归纳了肠道屏障损伤与肥胖及其相关代谢性疾病的研究进展,为临床如何评估患者肠道屏障功能以及如何通过改善肠道屏障功能治疗代谢性疾病提供理论基础.
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