Reduction of Post-Infarct Ventricular Tachycardia by Transplantation of Transgenic Cardiac Fibroblasts

M. Schiffer,E. Carls,S. Hildebrand,J. M. De La Fuente, M. Hesse,C. Geisen,A. Pfeifer,F. Bakhtiary,B. K. Fleischmann,W. Roell

The Thoracic and Cardiovascular Surgeon52nd Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery (DGTHG)（2023）

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摘要

Background: Loss of the gap junction protein connexin43 (Cx43) in the lesion area (IA) after myocardial infarction promotes the occurrence of ventricular tachycardia because (myo)fibroblasts (m)FB hardly express Cx43 and/or spike action potentials. To at least partially compensate this loss, we injected Cx43-(over)expressing cardiac FB into the IA and examined the effects on cardiac function and the incidence of ventricular tachycardia (VTi).

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transgenic cardiac fibroblasts,transplantation,post-infarct

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