Reduction of Post-Infarct Ventricular Tachycardia by Transplantation of Transgenic Cardiac Fibroblasts
The Thoracic and Cardiovascular Surgeon52nd Annual Meeting of the German Society for Thoracic and Cardiovascular Surgery (DGTHG)(2023)
摘要
Background: Loss of the gap junction protein connexin43 (Cx43) in the lesion area (IA) after myocardial infarction promotes the occurrence of ventricular tachycardia because (myo)fibroblasts (m)FB hardly express Cx43 and/or spike action potentials. To at least partially compensate this loss, we injected Cx43-(over)expressing cardiac FB into the IA and examined the effects on cardiac function and the incidence of ventricular tachycardia (VTi).
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关键词
transgenic cardiac fibroblasts,transplantation,post-infarct
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