Mitochondrial Targeted Curcumin Inhibits Glutathione Reductase and Modulates Mitochondrial Redox: A Potential Novel Strategy for the Treatment of Resistant NSCLC

Background: The dedicated thioredoxin and glutathione redox systems are the central antioxidant defense mechanisms by which mitochondria neutralize the excess ROS. In cancer, these antioxidant systems get upregulated to cope with oxidative stress insult caused due to dysfunctional mitochondria. These upregulated antioxidant systems lead to drug resistance in lung cancer.