Characterization of viral replication in different Hepatitis B virus-transgenic mice and its impact on antiviral signalling in vivo

Stefan Schefczyk,Xufeng Luo, Aojie Liang,Mike Hasenberg,Bernd Walkenfort,Simon Merz, Lea Bornemann,Martin Trippler,Mengji Lu,Heiner Wedemeyer, HartmutH. Schmidt, Ruth Broering

39. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der LeberZeitschrift für Gastroenterologie（2023）

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摘要

Background & Aims Pathogenesis of hepatitis B virus (HBV) infection is driven by innate and adaptive immunity. One aim of this study was to investigate how hepatitis B surface antigen (HBsAg) affects intrinsic antiviral signalling in HBV-transgenic mouse models that accumulate, lack or secrete the HBsAg. Another aim was to investigate how HBV HBsAg affects Kupffer cell populations in the different HBV-transgenic mouse strains.

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viral replication,virus-transgenic

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