Synthesis and Properties of Polymeric Rifabutin Forms with Different Types of Polymer–Antibiotic Bonding

Water-soluble polymeric forms of Rifabutin antitubercular drug, based on copolymers of acrylamide with 2-acrylamido-2-methylpropanesulfonic acid and of N -vinylpyrrolidone with 2-aminoethyl methacrylate, with ionic and covalent polymer–Rifabutin bonding were prepared. Polymeric carriers with the molecular mass of 7.5–98 kDa were prepared by radical copolymerization in alcohols at 60°С; the hydrodynamic radii R h-D of the polymer–Rifabutin complex and initial polymeric carrier were 2.6 and 2.35 nm, respectively. The Rifabutin content of the polymer systems was 14.1–43.4 mol %. The kinetics of the Rifabutin release from the polymeric forms in a model medium was estimated. Both types of the polymeric forms showed high activity toward M. smegmatis ATCC-607.