Gut microbiota promotes arterial thrombus formation in hyperlipidemic Ldlr-/- mouse model

Introduction The gut microbiota has been identified as a dynamic ecosystem impacting the vasculature and remote organ functions. Emerging research demonstrated that gut microbes are involved in modulating cardiovascular diseases (CVD). However, underlying molecular pathways that causally explain the role of the gut microbiota in thrombosis still remain obscure. Thus, we took advantage of established gnotobiotic low-density lipoprotein receptor-deficient (Ldlr-/-) mice to provide new insights on how the commensal gut microbiota, which is influenced by diet, modifies arterial thrombosis.