The Role of Imaging in Predicting Response to Chemotherapy and Radiotherapy in Sinonasal Malignancies: A Clinico-Pathological Correlative Study

Background: Over the past two decades, nonsurgical therapy has been increasingly utilized in advanced sinonasal malignancies with varying response rates. A complete response is associated with improved survival, and patients may be able to avoid surgical intervention. However, the ability of imaging to predict response to nonsurgical therapy is unclear. We aim to determine the positive predictive value (PPV) and negative predictive value (NPV) of MRI, CT scan, and PET in predicting response to non-surgical therapy by comparing the radiological report to the pathology report of the surgical resection.