An orthogonally activatable CRISPR-Cas13d nanoprodrug to reverse chemoresistance for enhanced chemo-photodynamic therapy

Zheng Liu,Zhiyuan Feng,Mohan Chen,Jiayin Zhan,Rong Wu,Yang Shi,Yunsheng Xue,Ran Liu,Jun-Jie Zhu,Jingjing Zhang

Chemical Science（2023）

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摘要

A logic-gated CRISPR-Cas13d-based nanoprodrug was rationally designed for orthogonal photomodulation of gene editing and prodrug release for enhanced chemo-photodynamic therapy.

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