Synthesis and evaluation of radioiodinated estrogens for diagnosis and therapy of male urogenital tumours

Feodor Braun,Marcel Jaschinski,Philipp Täger, Verena Marmann,Melanie von Brandenstein,Barbara Köditz,Thomas Fischer,Sergio Muñoz-Vázquez,Beate Zimmermanns,Markus Dietlein,Ferdinand Sudbrock, Phillip Krapf,Dietmar Fischer,Axel Heidenreich,Alexander Drzezga,Stefan Kirsch,Markus Pietsch,Klaus Schomäcker

Organic & Biomolecular Chemistry（2023）

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Abstract

We identified a new estrogen receptor (ER)-targeting ligand with picomolar affinity serving as vehicle for radioiodines. This ligand is a potential radiotheranostics for ER+ male tumours.

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