Mp16-12 kidney stones and osteoporosis: the bone-bowel-kidney axis

You have accessJournal of UrologyCME1 Apr 2023MP16-12 KIDNEY STONES AND OSTEOPOROSIS: THE BONE-BOWEL-KIDNEY AXIS Elizabeth Kwenda, Lucy Jiang, Sara Glover, and Victoria Bird Elizabeth KwendaElizabeth Kwenda More articles by this author , Lucy JiangLucy Jiang More articles by this author , Sara GloverSara Glover More articles by this author , and Victoria BirdVictoria Bird More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003236.12AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The aim of the study is to explore the prevalence of osteoporosis (OP) in patients with Crohn’s disease (CD) and kidney stones (KS). METHODS: A retrospective large-scale bioinformatics database, Information for Integrated Biology and Bedside depository data (i2b2) of the UF Health System was used to analyze the prevalence of osteoporosis in CD patients with KS and the general population from November 2011 to September 2017. The i2b2 repository database runs systematic query searches based on ICD and CPT codes used for institutional billing. Statistical analysis was performed using the SASv. 9.4 software. RESULTS: The total population was 1,002,357, ages 18-95 years old were 832,910. Males 18-95 years were 44.7%. In the general population, the prevalence of osteoporosis was 0.19%, 0.27%, 0.44%, 0.68%, 0.86%, 1.06%, 1.67% in males and 0.20%, 0.39%,0.93%, 2.55%, 5.11%, 6.70%, 9.16% females in the age groups 18-34, 35-44, 45-54, 55-64, 65-74, 75-84, >85 respectively. In the Crohn’s disease with kidney stones cohort, the prevalence of osteoporosis was 11.1%, 0%, 0%, 27.8%, 10.6%, 15.4%, 0% in males and 13.6%, 0%, 24%, 26.2%, 41.7%, 44.4%, 0% in females in the age groups 18-34, 35-44, 45-54, 55-64, 65-74, 75-84, >85 respectively. No patients or 0% of patient indicated osteoporosis but did not exclude osteopenia. The prevalence of osteoporosis in the CD with KS cohort was higher in the 18-35 year old group compared to the 85-95 year old general population in males: 11.1% vs. 1.67% (p<0.001) and females: 13.6% vs. 9.16% (p<0.001). CONCLUSIONS: The rate of OP in patients with CD and KS is significantly higher than the general population, most remarkable in the population under 35 years of age, this suggests a devastating premature aging process and the effects of the bowel on the kidney-bone axis. Further research on this subject is needed to identify the other variables that play a role in these findings. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e207 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Elizabeth Kwenda More articles by this author Lucy Jiang More articles by this author Sara Glover More articles by this author Victoria Bird More articles by this author Expand All Advertisement PDF downloadLoading ...