Mp77-10 stage and grade migration of prostate cancer during the covid-19 pandemic

You have accessJournal of UrologyCME1 Apr 2023MP77-10 STAGE AND GRADE MIGRATION OF PROSTATE CANCER DURING THE COVID-19 PANDEMIC Edoardo Beatrici, Muhieddine Labban, Benjamin V. Stone, Dejan K. Filipas, Nicola Frego, Sandeep S. Voleti, Nicolò Maria Buffi, Giovanni Lughezzani, Firas Abdollah, Adam S. Kibel, Alexander P. Cole, and Quoc-Dien Trinh Edoardo BeatriciEdoardo Beatrici More articles by this author , Muhieddine LabbanMuhieddine Labban More articles by this author , Benjamin V. StoneBenjamin V. Stone More articles by this author , Dejan K. FilipasDejan K. Filipas More articles by this author , Nicola FregoNicola Frego More articles by this author , Sandeep S. VoletiSandeep S. Voleti More articles by this author , Nicolò Maria BuffiNicolò Maria Buffi More articles by this author , Giovanni LughezzaniGiovanni Lughezzani More articles by this author , Firas AbdollahFiras Abdollah More articles by this author , Adam S. KibelAdam S. Kibel More articles by this author , Alexander P. ColeAlexander P. Cole More articles by this author , and Quoc-Dien TrinhQuoc-Dien Trinh More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003351.10AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The COVID-19 pandemic likely affected the healthcare system’s ability to deliver prostate cancer care services. Herein, we sought to evaluate prostate cancer's stage and grade migration resulting from the COVID-19 pandemic. METHODS: We retrospectively analyzed the National Cancer Database (NCDB) for men with prostate cancer between 2018-2020. We divided our cohort into the “Pre-Pandemic” (2018/2019) and “Pandemic” (2020) periods. Stage and grade of prostate cancer were stratified according to the severity of disease: PSA value (≤20 vs. >20), clinical T stage (cT1-T2 vs. cT3-T4), clinical M stage (cM0 vs. cM1), International Society of Uropathology (ISUP) grade group (ISUP 1-2-3 vs. ISUP 4-5), and D’Amico risk classification (low risk vs. intermediate & high risk). Pearson’s chi-square test was used to assess differences in the distribution of stage and grade across the two periods. We performed multivariable logistic regressions to estimate the effect of the “Pandemic” period on stage and grade distribution adjusting for clinical and socioeconomic covariates. RESULTS: A total of 398,719 men were diagnosed with prostate cancer during the “Pre-pandemic” (70.6%) and “Pandemic” (29.4%) periods (Table 1). On univariable comparisons, an increase in stage/grade across the two periods was demonstrated (all p<0.001). After adjusting for covariates, compared to the “Pre-pandemic”, the “Pandemic” period was associated with increased odds of PSA >20 levels (aOR 1.06; 95% CI 1.03 – 1.08; p-value <0.001), cT3-4 stages (aOR 1.12; 95% CI 1.08 – 1.16; p<0.001), cM1 stage (aOR 1.15; 95% CI 1.12 – 1.18; p<0.001), ISUP grade group 4 or 5 (aOR 1.03; 95% CI 1.01 – 1.05; p=0.003) and D’Amico Intermediate & High risk groups (aOR 1.15; 95% CI 1.13 – 1.18; p<0.001). CONCLUSIONS: The COVID-19 pandemic was associated with significant changes in the distribution of both stage and grade of prostate cancer. Possible explanations for this migration include a better selection of patients for prostate biopsy during the pandemic or changes in prostate cancer screening patterns. Source of Funding: None © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e1105 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Edoardo Beatrici More articles by this author Muhieddine Labban More articles by this author Benjamin V. Stone More articles by this author Dejan K. Filipas More articles by this author Nicola Frego More articles by this author Sandeep S. Voleti More articles by this author Nicolò Maria Buffi More articles by this author Giovanni Lughezzani More articles by this author Firas Abdollah More articles by this author Adam S. Kibel More articles by this author Alexander P. Cole More articles by this author Quoc-Dien Trinh More articles by this author Expand All Advertisement PDF downloadLoading ...