Mp29-18 oncological outcomes in the metastatic low tumor-burden prostate cancer are not significantly different from the locally advanced (t4 or n1) prostate cancer

You have accessJournal of UrologyCME1 Apr 2023MP29-18 ONCOLOGICAL OUTCOMES IN THE METASTATIC LOW TUMOR-BURDEN PROSTATE CANCER ARE NOT SIGNIFICANTLY DIFFERENT FROM THE LOCALLY ADVANCED (T4 OR N1) PROSTATE CANCER Toshikazu Tanaka, Shingo Hatakeyama, Ryuji Tabata, Fujita Naoki, Noro Daisuke, Itsuto Hamano, Takahiro Yoneyama, Yasuhiro Hashimoto, Satoshi Sato, Shintaro Narita, Tomonori Habuchi, and Chikara Ohyama Toshikazu TanakaToshikazu Tanaka More articles by this author , Shingo HatakeyamaShingo Hatakeyama More articles by this author , Ryuji TabataRyuji Tabata More articles by this author , Fujita NaokiFujita Naoki More articles by this author , Noro DaisukeNoro Daisuke More articles by this author , Itsuto HamanoItsuto Hamano More articles by this author , Takahiro YoneyamaTakahiro Yoneyama More articles by this author , Yasuhiro HashimotoYasuhiro Hashimoto More articles by this author , Satoshi SatoSatoshi Sato More articles by this author , Shintaro NaritaShintaro Narita More articles by this author , Tomonori HabuchiTomonori Habuchi More articles by this author , and Chikara OhyamaChikara Ohyama More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000003257.18AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: The difference in oncological outcomes between patients with locally advanced (T4 or N+) prostate cancer and metastatic prostate cancer with low tumor-burden disease remain unclear. We retrospectively compared the oncological outcomes between the locally advanced disease (M0-advanced group) and metastatic low-burden disease (M1-low group). METHODS: We evaluated 186 and 319 patients with the M0-advanced and M1-low groups treated with androgen deprivation therapy alone. Castration-resistant prostate cancer (CRPC)-free survival and overall survival were compared by a multivariable Cox regression analysis using inverse probability of treatment weighting method. We also evaluated risk factors for poor prognosis. RESULTS: Of 505, 138 (27.3%) patients underwent local interventions (surgery or radiotherapy). We observed no significant difference in CRPC-free survival and overall survival between the M0-advanced and M1-low groups. Multivariable Cox regression analysis showed that a Gleason score 9-10, T4 or N1 status, and no local intervention were significantly associated with poor prognosis. Local interventions are background difference for local intervention between the groups. CONCLUSIONS: Oncological outcomes of the group M1-low group were not significantly different from the M0-advanced. Gleason score, locally advanced status (T4 or N1), and local intervention potentially associate with oncological outcomes. Source of Funding: none © 2023 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 209Issue Supplement 4April 2023Page: e389 Advertisement Copyright & Permissions© 2023 by American Urological Association Education and Research, Inc.MetricsAuthor Information Toshikazu Tanaka More articles by this author Shingo Hatakeyama More articles by this author Ryuji Tabata More articles by this author Fujita Naoki More articles by this author Noro Daisuke More articles by this author Itsuto Hamano More articles by this author Takahiro Yoneyama More articles by this author Yasuhiro Hashimoto More articles by this author Satoshi Sato More articles by this author Shintaro Narita More articles by this author Tomonori Habuchi More articles by this author Chikara Ohyama More articles by this author Expand All Advertisement PDF downloadLoading ...