Synergistic action of carvedilol and clomiphene in mitigating the behavioral phenotypes of letrozole-model of PCOS rats by modulating the NRF2/NFKB pathway

Olabode Oluwadare Akintoye,Ayodeji Johnson Ajibare,Isaac Adeola Oriyomi,Babatunde Ajayi Olofinbiyi, Grace Oyiza Yusuf, Damilola Christanah Afuye,Temitope Kabirat Babalola, Oluwadamilola Esther Faturoti,Seun Oludipe,Victor Bamidele Owoyele

SSRN Electronic Journal（2023）

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摘要

Study showed that the combination of carvedilol and clomiphene citrate has anxiolytic potential and improved cognitive functions in PCOS rats. This might have been achieved by carvedilol and clomiphene citrate's ability to modulate the cholinergic system and the Nrf2 pathway while downregulating the NFκB signaling pathway.

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pcos rats,clomiphene,carvedilol,letrozole-model

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