Supplementary Figures from CBX8 Exhibits Oncogenic Activity via AKT/β-Catenin Activation in Hepatocellular Carcinoma

Supplementary Figures contain the following contents: The expression of Chromobox genes in HCC (Figure S1). Data analysis from TCGA database (Figure S2). The expression of CBX8 in several types of tumors (Figure S3). The prognostic value of CBX8 in HCC (Figure S4). The protein expression of CBX8 in HCC (Figure S5). The effect of CBX8 on cell proliferation and migration (Figure S6). Tumor weight in xenograft models (Figure S7). Expression of CBX8 and vimentin in lung metastasis (Figure S8). Analysis of gene microarray (Figure S9). Pathway enrichment analyses of RNA-seq (Figure S10). The effects of β-catenin and MAPK pathways on CBX8-mediated phenotypes (Figure S11). The association of CBX8 and EGR1 in HCC (Figure S12). The effect of PRC1 on CBX8-mediated phenotypes (Figure S13). Effects of EGR1 siRNAs (Figure S14). The requirement of EGR1 for CBX8-mediated malignances (Figure S15). Bioinformatics for miR-365a-3p (Figure S16). The CBX8-mediated regulation of EGR1 and miR-365a-3p (Figure S17). The effects of CBX1, CBX4, CBX7 and CBX8 on HCC cell proliferation and migration (Figure S18). The modulation of CBX8 by miR-410-3p (Figure S19).