Supplementary Figures 1 - 6 from Durable Adoptive Immunotherapy for Leukemia Produced by Manipulation of Multiple Regulatory Pathways of CD8<sup>+</sup> T-Cell Tolerance

PDF file - 643K, Supplementary Figure S1. Surface expression of co-stimulatory and co-inhibitory molecules on FBL tumor cells. Supplementary Figure S2. Transferred T cells are deleted via apoptosis. Supplementary Figure S3. Survival of transferred T cells is not sufficient for acquisition of effector function. Supplementary Figure S4. Systemic inflammation and provision of high-dose IL-2 fail to prevent deletion of adoptively transferred CD8+ T cells. Supplementary Figure S5. LAG3 blockade has limited additional impact on survival of transferred T cells. Supplementary Figure S6. LAG3 blockade combines with PD-1/CTLA4 blockade to promote expansion and effector function by transferred T cells.