Supplementary Figure 1 from Evaluating Patient-Derived Colorectal Cancer Xenografts as Preclinical Models by Comparison with Patient Clinical Data

Genomic alterations of IGF2-PI3K pathway in MSS human colorectal cancer cell lines. A. Gene expression, gene copy number and mutation data provided by the Cancer Cell Line Encyclopedia were studied in the 36 MSS cell lines out of the cohort of the 62 human colorectal cell lines. Tumors were considered to be amplified if the gene copy number was >3. Gene overexpression is defined by an expression superior to average in all CRC cell line panel + 1 SD. B. Alteration frequencies are expressed as a percentage of the MSS cell lines in green. Data obtained in non-hypermutated patient tumor samples reported by the The Cancer Genome Atlas are noted in red.