Supplementary Materials and Methods and Figure Legends and Figures from Combination of Antibody That Inhibits Ligand-Independent HER3 Dimerization and a p110α Inhibitor Potently Blocks PI3K Signaling and Growth of HER2+ Breast Cancers

PDF file, 511K, Supplementary Figure 1. LJM716 and p110alpha inhibitor synergistically inhibit tumor cell growth. Supplementary Figure 2. HER3 antibody sensitizes cells to PI3Kalpha inhibitor in colony forming assays. Supplementary Figure 3. HER3 antibody sensitizes cells to PI3Kalpha inhibitor in three-dimensional growth assays. Supplementary Figure 4. LJM716, BYL719, or the combination of the two significantly reduce S473 P-AKT levels in vivo.