Supplementary Methods, Figures 1 -2 from Identification of ATR–Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity

Supplementary Materials and Methods. Supplementary Figure S1: Cell viability in various concentrations of DNA-damaging agents and novel ATR pathway inhibitors. Supplementary Figure S2: Effects of novel and established ATR pathway inhibitors on Chk1 phosphorylation induced by hydroxyurea or cisplatin as assessed by flow cytometry.