Data Supplement from Genetic Ablation of Metadherin Inhibits Autochthonous Prostate Cancer Progression and Metastasis

Supplementary Methods, Figures 1-5, Table 1. Supplementary Materials and Methods. Supplemental Figure S1. Whole-organism knockout of Mtdh does not affect prostate gland development. Supplemental Figure S2. Mtdh ablation does not affect the expression of Probasin promoter-driven expression of SV40 antigens. Supplemental Figure S3. Loss of Mtdh inhibits the formation of diverse subtypes of prostate cancer in TRAMP mice. Supplemental Figure S4. Analyses of proliferation and apoptosis indices in prostate tissues from TRAMP/Mtdh+ and TRAMP/Mtdh- mice. Supplemental Figure S5. Silencing of Mtdh in TRAMP-C1 tumor cells impairs tumor formation in vivo. Supplemental Table 1: Clinical sample information for IHC and FISH analysis.