Supplementary Movie 1 from Emergence of Drug Tolerance in Cancer Cell Populations: An Evolutionary Outcome of Selection, Nongenetic Instability, and Stress-Induced Adaptation

Supplementary Movie 1. The cell population moving through the phenotype space during one simulation of the individual-based model. In this case there are some DTPs present in the initial population (5%) together with the PC9 cells (95%). Individual cells are shown as blue circles, whereas the population mean phenotype is shown as a dotted magenta line. The movie shows that the PC9s quickly die out, allowing the DTPs to emerge, followed by the DTEPs.