Supplementary Figures 1 - 10 from LEF1 and B9L Shield β-Catenin from Inactivation by Axin, Desensitizing Colorectal Cancer Cells to Tankyrase Inhibitors

PDF file - 4151K, Fig S1 Molecular targets of beta-catenin inhibitors. Fig S2 Efficacy and toxicity of beta-catenin inhibitors. Fig S3 Effects of TNKSi on Wnt signaling components. Fig S4 TNKSi-induced Axin degradasomes. Fig S5 TNKSi treatment of COLO320 cells. Fig S6 Prolonged TNKSi treatment and beta-catenin stability. Fig S7 TNKSi of chronically Wnt-stimulated HeLa cells. Fig S8 TNKSi responses of Wnt-stimulated cells. Fig S9 CA treatment of mice. Fig S10 Comparison of LEF1 antibodies.