Supplementary Figure from NSD2 Is Recruited through Its PHD Domain to Oncogenic Gene Loci to Drive Multiple Myeloma

PDF file, 989K, Depletion of NSD2 has only mild effects on myeloma cell proliferation. Supplementary Figure S2. NSD2 is important for tumorigenesis of t(4;14)+ myeloma cells. Supplementary Figure S3. PHD domains are important for cellular H3K36me2 activity of NSD2 but not in vitro enzymatic activity. Supplementary Figure S4. NSD2 activity mediates transcription activation of t(4;14)+ specific myeloma gene set. Supplementary Figure S5. NSD2 overexpression driven by t(4;14) translocation abolished global association of H3K36me2 with gene transcription. Supplementary Figure S6. NSD2 overexpression driven by t(4;14) translocation abolished positive correlation of H3K36me2 with gene transcription.