Supplementary Figures 1 through 7 from miR-29b Mediates NF-κB Signaling in KRAS-Induced Non–Small Cell Lung Cancers

Supplementary Fig. 1: Ectopic PIK3CAH1047R expression induces a modest activation of the EGFR downstream signaling pathway in BEAS-2B clones. Supplementary Fig. 2: the steady state level of miR-29b and the relative copy number of the miR-29b2 locus are significantly correlated in KRAS/EGFR wildtype tumors. Supplementary Fig. 3: miR-138 expression is not induced by mutant KRAS or mutant EGFR in adenocarcinoma tissues. Supplementary Fig. 4: Inhibitors of the EGFR signaling pathway downregulate expression of key downstream effectors. Supplementary Fig. 5: miR-29b confers resistance to TNFalpha+ActD-induced apoptosis. Supplementary Fig. 6: TNFAIP3 is a target of miR-29b. Supplementary Fig. 7: miR-29b sensitizes A549 cells to cisplatin-induced apoptosis.