Supplementary Figures 1 - 6, Tables 1 - 3 from Transcription Poisoning by Topoisomerase I Is Controlled by Gene Length, Splice Sites, and miR-142-3p

PDF file - 2059K, Importance of Exon numbers for transcript downregulation by CPT (SF1); CPT up-regulates the p53 signaling pathway genes (SF2); Down-regulation of RNA degradation-related genes after CPT treatment (SF3); Down-regulation of ubiquitin-related genes after CPT treatment (SF4); Top1 down-regulation does not impacts gene expression for CUL5 and UBE2W (SF5); miR-142-3p decreases cell survival, and down-regulation of its target genes BCL2L1 and MAP3K7IP2 sensitize to CPT (SF6). *** List of Primers (ST1); List of the 3808 down-regulated genes in CPT-treated HCT116 cells, by 2-fold or more (ST2); List of the 835 up-regulated genes in CPT-treated HCT116 cells, by 2-fold or more (ST3).