Supplemental Figures S1-S11 from PBX3 and MEIS1 Cooperate in Hematopoietic Cells to Drive Acute Myeloid Leukemias Characterized by a Core Transcriptome of the <i>MLL</i>-Rearranged Disease

Flow cytometry analysis of leukemic bone marrow cells from recipient mice of primary BM transplantation (S1); Comparison of leukemic latency between secondary BMT recipient mice transplanted with primary leukemic BM cells from two donor mice of each group (S2); Gene Set Enrichment Analysis of genes differentially expressed between different groups of samples (S3); Gene Set Enrichment Analysis of gene sets that are significantly differentially enriched between Group 2 samples and the PBX3+MEIS1 samples (S4); Analysis of genes significantly differentially expressed between three hierarchical clustering groups (S5); Heatmap of expression profiles of the 211 genes that are expressed at a significantly lower level in Group 3 than in both Groups 1 and 2 (S6); Heatmap of expression profiles of the 279 genes that are expressed at a significantly higher level in Group 2 than in both Groups 1 and 3 (S7); Heatmap of expression profiles of the 85 genes that are expressed at a significantly lower level in Group 2 than in both Groups 1 and 3 (S8); Heatmap of expression profiles of a set of 166 genes that are expressed at a significantly higher level in Group 1 than in both Groups 2 and 3, and are also associated with cell death/apoptosis and hematopoietic cell differentiation pathways according to DAVID analysis (S9); Heatmap of expression profiles of representative gene sets that are expressed at a significantly lower level in Group 3 samples than in both Groups 1 and 2 samples (S10); The effect of forced expression of HOXA9 on the expression of endogenous Hoxa genes in PBX3+MEIS1 AML cells (S11).