Supplementary Figures 1-8 from GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome

Supplementary Figure 1. Silencing p53 expression in intestine of p53int-/- mice eliminates phospho-p53 responses to DNA damage induced by radiation. Supplementary Figure 2. Silencing p53 expression in intestine of p53int-/- mice amplifies RIGS-related toxicity. Supplementary Figure 3. Littermates are utilized to minimize the effect of genetic backgrounds in transgenic mice. Supplementary Figure 4. HCT116 cells do not exhibit GUCY2C ligand binding. Supplementary Figure 5. Total body irradiation induces gastrointestinal injury. Supplementary Figure 6. Hormone expression is preserved in RIGS in Gucy2c-/- mice. Supplementary Figure 7. Oral ST fails to oppose RIGS in the absence of GUCY2C. Supplementary Figure 8. Silencing p53 expression in intestine of p53int-/- mice does not affect apoptosis in RIGS.