Figure S1-S4 from Antitumor Effects of Blocking Protein Neddylation in T315I-BCR-ABL Leukemia Cells and Leukemia Stem Cells

Figure S1 - p53-Null K562 and KCL-22 cells were resistance to MLN4924; Figure S2 - MLN4924 induces apoptosis in IM-sensitive and -resistant CML cells harboring WT-p53 in a time-dependent fashion; Figure S3 - MLN4924 suppresses survival of BCR-ABL+ CML LSCs in vivo; Figure S4 - p27kip1 knockdown attenuates the effect of MLN4924 on CML LSCs in vivo.