Supplementary Figures from SENP1 deSUMOylates and Regulates Pin1 Protein Activity and Cellular Function

Supplementary Figures - PDF file 635K, Supplementary Figure S1. Pin1 is modified on Lys6 and Lys63 by SUMO1 in vitro and in vivo. Supplementary Figure S2. Pin1 Lys6 and Lys63 mutations increase its ability to active cyclin D1 promoter and stabilize cyclin D1 protein in cells. Supplementary Figure S3. SENP1 binds Pin1 and thereby positively regulates cyclin D1 activation