Supplementary Figures S1-S8 from Ubiquitin-Specific Protease 4-Mediated Deubiquitination and Stabilization of PRL-3 Is Required for Potentiating Colorectal Oncogenesis

Expression of USP4 in CRC cell lines (S1); Knockdown of USP4 impairs CRC cell proliferation (S2); The degree of USP4 depletion in tumors (S3); Depletion of USP4 inhibits pulmonary metastasis in nude mice (S4); PRL-3 is indispensable for the oncogenic functions of USP4 (S5); USP4 does not affect PRL-3 mRNA expression (S6); Expression of USP4 does not Correlate with PRL-3 mRNA Levels (S7); USP4 protein levels is positively correlated with PRL-3 protein levels in xenografts (S8).