Supplementary Figures 1 through 5 and Supplementary Figure Legends from p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance

Supplementary Figure 1. The p53 pathway is functional in Th-MYCN neuroblastomas. Supplementary Figure 2. Immunohistochemical analysis of Th-MYCN mice. Supplementary Figure 3. Restoration of p53 has no effect on tumor growth rate or penetration in Th-MYCN/Trp53KI/KI mice. Supplementary Figure 4. Th-MYCN/Trp53KI/KI pups display increased percentage of neoplastic islands compared to Th-MYCN/Trp53WT/WT pups. Supplementary Figure 5. Figure S5 Th-MYCN/Trp53WT/WT and Th-MYCN/Trp53KI/K tumors are similar in their basal DNA damage levels.