Supplementary Figure S2 from TRAP1 Is Involved in BRAF Regulation and Downstream Attenuation of ERK Phosphorylation and Cell-Cycle Progression: A Novel Target for BRAF-Mutated Colorectal Tumors

A. Gene ontology categories associated to genes up/downregulated upon TRAP1 silencing in HCT116 cells. B. Top predicted biofunctions associated to genes downregulated upon TRAP1 silencing in HCT116 cells. Color intensity for each biofunction corresponds to p-value. Biofunction prediction from Fidea software. C. Real time gene expression analysis of previously validated genes in HT29 cells upon TRAP1 transient interference (*p=<0.0001; **p=0.003; ***p=0.002; {degree sign}p=0.001). Insert: TRAP1 expression evaluated by immunoblot in scramble (1) and siTRAP1 (2) HT29 cells.