Supplementary Figures 1 - 4 from G-protein Inactivator RGS6 Mediates Myocardial Cell Apoptosis and Cardiomyopathy Caused By Doxorubicin

PDF file - 251K, Figure S1. RGS6 is an essential mediator of Dox-induced increases in p53 in mouse atrium. Figure S2. Quantification of key apoptotic signaling proteins in ventricles of mice treated with Dox. Figure S3. Induction of RGS6 by Dox is transient and requires de novo protein synthesis. Figure S4. Schematic illustration of RGS6-mediated ventricular dysfunction induced by Dox.