Supplementary Figures S1-S5 from Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination

Receiver operating characteristic (ROC) curve and foci decay ratios from our retrospective study ; Induction of gene expression upon irradiation calculated within each individual patient (indicated by the index on the x-axis) for three selected radiation-sensitive genes ; Enrichment of the set of 439 probesets included in the HALLMARK P53 PATHWAY geneset that was strongly induced upon irradiation ; Volcano plots for the comparison of response to irradiation between Grade 3, 2, 1 and Grade 0 patients ; Receiver operating characteristic curve for the mean log2 fold inductions of the HR geneset .