Supplementary Figure 3 from Maximizing the Efficacy of MAPK-Targeted Treatment in <i>PTEN</i><sup>LOF</sup><i>/BRAF</i><sup>MUT</sup> Melanoma through PI3K and IGF1R Inhibition
crossref(2023)
摘要
Despite major dependence of PTENLOF/BRAFMUT melanoma cell lines on PI3Kβ, PI3Kαi synergizes with PI3Kβi to inhibit downstream signaling upon long-term treatment. A) +B) Effects of treatment with the indicated inhibitors as single-agents or in combination for 2h (A) and 72h (B) on PI3K signaling was determined by immunoblotting in PTENLOF/BRAFMUT melanoma cell lines. PI3Kβi=rac-KIN-193, PI3Kαi=BYL719, PI3Kδi=CAL101
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