BRCA1基因突变诱导乳腺癌发生机制综述
Da Jian Kang(2023)
Abstract
乳腺癌易感基因1(BRCA1)是重要的抑癌基因。其通过同源重组来调控细胞周期和维持细胞基因组完整性,在DNA修复中发挥重要作用。BRCA1基因发生遗传突变的女性患乳腺癌和卵巢癌的风险极高,但很少患其他类型癌症。本文对BRCA1基因参与乳腺癌发生的机制进行综述。
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