八宝灌肠方治疗脾虚湿蕴型慢性溃疡性直肠炎临床观察
Shanxi Journal of Traditional Chinese Medicine(2023)
Abstract
目的:观察八宝灌肠方治疗脾虚湿蕴型慢性溃疡性直肠炎的临床疗效.方法:选取62例慢性溃疡性直肠炎患者,随机分为两组各31例.治疗组予八宝灌肠方灌肠治疗,睡前保留灌肠;对照组予美沙拉嗪灌肠液治疗.结果:治疗组与对照组的中医证候疗效总有效率分别为89.58%和77.08%,差异有统计学意义(P<0.05).两组治疗后临床症状评分均较治疗前下降(P<0.05);治疗组治疗后症状评分较对照组下降明显(P<0.01).两组治疗后内镜下肠黏膜病变评分及炎症疾病活动指数均较治疗前明显改善(P<0.05);治疗组评分显著低于对照组(P<0.05).两组治疗前后肠杆菌、肠球菌均较治疗前明显降低(P<0.05),乳酸菌、双歧杆菌均较治疗前明显升高(P<0.05);治疗组治疗后明显优于对照组(P<0.05).结论:八宝灌肠方能改善慢性溃疡性直肠炎患者的临床症状、优化肠道菌群结构、缓解炎症反应.
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